ea0065p356 | Reproductive Endocrinology and Biology | SFEBES2019
Sachania Svaty
, Nawar Naushin
, Ghelut Aaron
, Dhillo Waljit
, Jonas Kim C
Kisspeptin (Kp) and its receptor (KISS1R) are essential for reproduction, with dysfunction in their activities leading to reproductive disorders, such as precocious puberty and hypogonadotrophic hypogonadism. Kp is synthesised and secreted within specialist nuclei of the hypothalamus, modulating the HPG axis. Kp is a 54 amino acid peptide, which can undergo proteolytic cleavage into smaller peptides, including Kp10, which retain biological activities. However, little is known ...